| Open position for CSC PhD student |
Protein-protein interactions make up a focal point of research in
both academia and industry to
develop e.g. better targeted cancer therapeutics. In recent years,
fluorescence-based super-
resolution microscopy has had a remarkable development, manifested
e.g. by the Nobel Prize in
Chemistry in 2014. Together with the specificity and single-molecule
detection sensitivity achievable
with fluorescence methods, this development will in the next-coming
years likely profoundly
transform our view of cellular and molecular biology. Our research
group at KTH has a leading role
in this development. We now seek a PhD student to be engaged in a
project, with the aim to
further develop single-molecule Fluorescence Correlation Spectroscopy
(FCS), super-
resolution and multi-parameter fluorescence techniques, combine these
with microfluidics, to
study protein interactions in individual cells with utmost sensitivity
and resolution. The focus
is to reveal the dynamics and interactions of central membrane
proteins in living cells, to better
understand their mechanisms. Simultaneously, the aim is also to push
the fluorescence
methodology development. The latter comprises not only instrumentation
development, but
also e.g. development of new fluorescence data analyses, design of
labeling, and optimization
of fluorescence emission properties of the labeled fluorophores used
in the measurements.
|
| For further info: Please, contact professor Jerker Widengren
(jwideng@kth.se) |
|
